Immediate hypersensitivity to corticosteroids.
J Investig Allergol Clin Immunol
; 16(1): 51-6, 2006.
Article
em En
| MEDLINE
| ID: mdl-16599249
ABSTRACT
INTRODUCTION:
In comparison with the extremely frequent use of corticosteroids in different diseases, immediate allergic reactions remain uncommon. In addition to the steroid molecule, the causative agent of these reactions can be an excipient. MATERIAL ANDMETHODS:
We report seven cases of immediate reactions induced by different preparations of corticosteroids. Skin tests with the suspected steroid and excipients were carried out. In patients with negative skin tests, oral or parenteral challenges were performed with the drug and the excipients involved. Challenge tests with at least two other corticosteroids belonging to another or even the same group of the Coopman classification were carried out.RESULTS:
Of the 7 patients, six had positive skin tests with the suspected preparation of corticoid three cases with methylprednisolone acetate, two cases with carboxymethylcellulose and one case with the complete triamcinolone preparation. Only in one case did we have to challenge with the suspected steroid preparation to confirm the diagnosis. All challenge tests with other corticosteroids belonging to another or to the same group of the Coopman classification were negative.CONCLUSIONS:
The reactions were caused by the steroid molecule (Triamcinolone or methylprednisolone succinate) in four patients, by an excipient (carboxymethylcellulose) in another two patients and we could not identify the sensitized molecule in one patient. We did not demonstrate cross-reactivity between different corticosteroids.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metilprednisolona
/
Triancinolona
/
Corticosteroides
/
Hipersensibilidade a Drogas
/
Hipersensibilidade Imediata
/
Anti-Inflamatórios
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Investig Allergol Clin Immunol
Ano de publicação:
2006
Tipo de documento:
Article