Dihydrogenated ergot compounds bind with high affinity to GABAA receptor-associated Cl- ionophore.
Eur J Pharmacol
; 202(1): 109-11, 1991 Sep 04.
Article
em En
| MEDLINE
| ID: mdl-1664802
ABSTRACT
The binding of t-[3H]butylbicycloorthobenzoate ([3H]TBOB) to crude synaptosomal membranes of the mouse brain (cerebrum minus cortex) in the presence of dihydroergotoxine, dihydroergosine, dihydroergotamine and gamma-aminobutyric acid (GABA) was studied in vitro. [3H]TBOB binding was inhibited by all drugs used. The rank order of potency was dihydroergotoxine greater than GABA greater than dihydroergosine greater than dihydroergotamine. This suggests that dihydrogenated ergot compounds, especially dihydroergotoxine, possess appreciable binding activity (comparable to that of benzodiazepines and barbiturates) at the GABAA receptor-associated C1- ionophore.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Bicíclicos com Pontes
/
Receptores de GABA-A
/
Compostos Bicíclicos Heterocíclicos com Pontes
/
Alcaloides de Claviceps
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1991
Tipo de documento:
Article