[Aging of the osseous tissue. Theoretical basis for new directions of mechanotransduction optimization].

ABSTRACT

On the basis on literature studies and the results of personal studies, the authors describe ultra- and micro-structural changes in the osseous tissue associated with the process of aging. Functional disturbances in tissue processes causing osseous tissue loss and osteoporosis development are characterized. It is suggested that the described changes are induced by age-dependent hypermineralization of the osseous tissue with the consequent disturbances of mechano-transduction. A hypothesis is discussed concerning a novel approach to pharmacological treatment of osteoporosis. Development of a new group of drugs controlling the calcium exchange between the osseous compartment and the blood is considered. Presumed pathogenetic and clinical effects of these drugs are described.