Delays in neuronal differentiation in Mash1/Ascl1 mutants.
Dev Biol
; 295(1): 67-75, 2006 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-16677628
ABSTRACT
The inactivation of a developmental transcription factor may lead to the complete absence of a specific cell type. More commonly, though, it only partially impairs its generation. The modalities of this partial effect have rarely been documented in any detail. Here, we report a novel function for the bHLH transcription factor Ascl1/Mash1 in the generation of the nucleus of the solitary tract (nTS). In Mash1(-/-) late embryos, the nTS is markedly atrophic. Tracing back the origin of this atrophy, we show that nTS precursors appear in the mutants 1 day later than in the wild type and then accumulate at a slower pace. We also show that the previously reported atrophy of the sympathetic chain in Mash1 mutants is similarly preceded by a delay of 1 to 2 days in the appearance of differentiated ganglionic cells. Finally, we provide evidence that the acceleration imposed by Mash1, regardless of the production of post-mitotic cells, affects differentiation itself, both generic and type-specific.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
/
Núcleo Solitário
/
Fatores de Transcrição Hélice-Alça-Hélice Básicos
/
Mutação
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Dev Biol
Ano de publicação:
2006
Tipo de documento:
Article