Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors.

Varaprasad, Chamakura V N S; Barawkar, Dinesh; El Abdellaoui, Hassan; Chakravarty, Subrata; Allan, Matthew; Chen, Huanming; Zhang, Weijian; Wu, Jim Z; Tam, Robert; Hamatake, Robert; Lang, Stanley; Hong, Zhi

Varaprasad, Chamakura V N S; Barawkar, Dinesh; El Abdellaoui, Hassan; Chakravarty, Subrata; Allan, Matthew; Chen, Huanming; Zhang, Weijian; Wu, Jim Z; Tam, Robert; Hamatake, Robert; Lang, Stanley; Hong, Zhi.

Afiliação

Varaprasad CV; Drug Discovery, Valeant Pharmaceutical Research and Development, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. vchamakura@valeant.com

Bioorg Med Chem Lett ; 16(15): 3975-80, 2006 Aug 01.

Article em En | MEDLINE | ID: mdl-16725322

ABSTRACT

ABSTRACT

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles were discovered as potent in vitro MEK1 inhibitors.

Assuntos

Inibidores Enzimáticos/farmacologia; MAP Quinase Quinase 1/antagonistas & inibidores; Tiazóis/farmacologia; Desenho de Fármacos

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / MAP Quinase Quinase 1 / Inibidores Enzimáticos Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2006 Tipo de documento: Article

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