Effects of anxiolytic drugs on escape behavior induced by dorsal central gray stimulation in rats.
Physiol Behav
; 49(1): 125-9, 1991 Jan.
Article
em En
| MEDLINE
| ID: mdl-1673252
ABSTRACT
Each animal was chronically implanted with bipolar electrodes in dorsal central gray matter (DCG) and was trained to press a lever to decrease the DCG-stimulation current. Chlordiazepoxide (5-20 mg/kg, PO), diazepam (2-10 mg/kg, PO) and bromazepam (1-5 mg/kg, PO) produced dose-dependent increases in the DCG-stimulation threshold 1-4 h after administration without affecting motor performance. Meprobamate (200 mg/kg, PO) and pentobarbital (10 mg/kg, PO) also slightly increased the stimulation threshold. Their potency was in the order of bromazepam greater than diazepam greater than chlordiazepoxide greater than pentobarbital greater than meprobamate. The increase in the threshold induced by diazepam (10 mg/kg, PO) was inhibited by the GABA antagonists, bicuculline (1 mg/kg, IP) and picrotoxin (0.1 mg/kg, IP). These results suggest that decreased susceptibility to brain stimulation is involved in suppressing effects of anxiolytic drugs on the escape behavior, and also that the antiaversive action of benzodiazepines may be related to a GABAergic mechanism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nível de Alerta
/
Aprendizagem da Esquiva
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Ansiolíticos
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Substância Cinzenta Periaquedutal
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Antagonistas GABAérgicos
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Diazepam
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Reação de Fuga
Limite:
Animals
Idioma:
En
Revista:
Physiol Behav
Ano de publicação:
1991
Tipo de documento:
Article