Enhancement of aorta tonus evoked by hypertonic solutions is endothelium-dependent.
Gen Pharmacol
; 22(1): 133-6, 1991.
Article
em En
| MEDLINE
| ID: mdl-1675614
ABSTRACT
1. The effect of NaCl hypertonic solutions on the contractions induced by noradrenaline or prostaglandin F2 alpha and on the relaxant effect of acetylcholine and sodium nitroprusside was investigated in aortae with or without endothelium isolated from rats. 2. Hypertonic solutions enhanced the contractions elicited by the vasoconstrictor agents in preparations with endothelium and this phenomenon was not altered by previous treatment of the animals with reserpine or the preparations with methylene blue or indomethacin. 3. In hypertonic medium acetylcholine but not sodium nitroprusside vasodilator effect was inhibited. 4. We suggest that NaCl hypertonic solutions modify vascular reactivity probably through (i) the release of an endothelium-derived contracting factor not sensitive to cyclooxygenase inhibitors; (ii) a diminished release of an endothelium-derived relaxing factor not related to the cGMP system.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
/
Soluções Hipertônicas
/
Músculo Liso Vascular
/
Tono Muscular
Limite:
Animals
Idioma:
En
Revista:
Gen Pharmacol
Ano de publicação:
1991
Tipo de documento:
Article