Modelling cytomegalovirus replication patterns in the human host: factors important for pathogenesis.
Proc Biol Sci
; 273(1596): 1961-7, 2006 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-16822758
ABSTRACT
Human cytomegalovirus can cause a diverse range of diseases in different immunocompromised hosts. The pathogenic mechanisms underlying these diseases have not been fully elucidated, though the maximal viral load during infection is strongly correlated with the disease. However, concentrating on single viral load measures during infection ignores valuable information contained during the entire replication history up to the onset of disease. We use a statistical model that allows all viral load data sampled during infection to be analysed, and have applied it to four immunocompromised groups exhibiting five distinct cytomegalovirus-related diseases. The results show that for all diseases, peaks in viral load contribute less to disease progression than phases of low virus load with equal amount of viral turnover. The model accurately predicted the time of disease onset for fever, gastrointestinal disease and pneumonitis but not for hepatitis and retinitis, implying that other factors may be involved in the pathology of these diseases.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
/
Modelos Estatísticos
/
Hospedeiro Imunocomprometido
/
Infecções por Citomegalovirus
/
Citomegalovirus
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Proc Biol Sci
Ano de publicação:
2006
Tipo de documento:
Article