Elevated childhood serotonergic function protects against adolescent aggression in disruptive boys.
J Am Acad Child Adolesc Psychiatry
; 45(7): 833-40, 2006 Jul.
Article
em En
| MEDLINE
| ID: mdl-16832320
ABSTRACT
OBJECTIVE:
This longitudinal study examined whether responsiveness of the neurotransmitter serotonin (5-HT) in childhood predicts adolescent aggression.METHOD:
Boys (N = 33) with disruptive behavior disorders who received assessments of central 5-HT function via the prolactin response to fenfluramine between 1990 and 1994 when they were 7 to 11 years old were re-evaluated clinically on average 6.7 years later.RESULTS:
After accounting for baseline aggression, early 5-HT function accounted for a significant proportion of variance in adolescent aggression. This prospective relationship of childhood 5-HT function with adolescent aggression (r = -0.71) and antisocial behavior (r = -0.59) was found primarily in adolescents who were aggressive during childhood. Irrespective of childhood aggression, no child with high 5-HT function was particularly aggressive at follow-up.CONCLUSIONS:
Low childhood 5-HT function appears important, but not sufficient, for the emergence of adolescent aggression. However, early high 5-HT function may protect against adolescent violence and aggression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prolactina
/
Serotonina
/
Comportamento do Adolescente
/
Serotoninérgicos
/
Transtorno da Conduta
/
Agressão
/
Fenfluramina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Humans
/
Male
Idioma:
En
Revista:
J Am Acad Child Adolesc Psychiatry
Ano de publicação:
2006
Tipo de documento:
Article