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Long-term atomoxetine treatment in adolescents with attention-deficit/hyperactivity disorder.
Wilens, Timothy E; Newcorn, Jeffrey H; Kratochvil, Christopher J; Gao, Haitao; Thomason, Christine K; Rogers, Ann K; Feldman, Peter D; Levine, Louise R.
Afiliação
  • Wilens TE; Massachusetts General Hospital, Department of Psychiatry, Boston, Massachusetts, USA. twilens@partners.org
J Pediatr ; 149(1): 112-9, 2006 Jul.
Article em En | MEDLINE | ID: mdl-16860138
ABSTRACT

OBJECTIVE:

To determine the efficacy and safety of atomoxetine in adolescent subjects treated for attention-deficit/hyperactivity disorder (ADHD) for up to 2 years. STUDY

DESIGN:

Data from 13 atomoxetine studies (6 double-blind, 7 open-label) were pooled for subjects age 12 to 18 with ADHD as defined by the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders IV.

RESULTS:

Of the 601 atomoxetine-treated subjects in this meta-analysis, 537 (89.4%) completed 3 months of acute treatment. A total of 259 subjects (48.4%) are continuing atomoxetine treatment; 219 of these subjects have completed at least 2 years of treatment. The mean dose of atomoxetine at endpoint was 1.41 mg/kg/day. Mean ADHD Rating Scale IV, parent version, investigator-administered and -scored total scores showed significant improvement (P < .001) over the first 3 months. Symptoms remained improved up to 24 months without dosage escalation. During the 2-year treatment period, 99 (16.5%) subjects discontinued treatment due to lack of effectiveness, and 31 (5.2%) subjects discontinued treatment due to adverse events. No clinically significant abnormalities in height, weight, blood pressure, pulse, mean laboratory values, or electrocardiography parameters were found.

CONCLUSIONS:

Two-year data from this ongoing study indicate that atomoxetine maintains efficacy among adolescents with ADHD, with no evidence of drug tolerance and no new or unexpected safety concerns.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propilaminas / Transtorno do Deficit de Atenção com Hiperatividade / Inibidores da Captação Adrenérgica Tipo de estudo: Clinical_trials / Guideline / Systematic_reviews Limite: Adolescent / Female / Humans / Male Idioma: En Revista: J Pediatr Ano de publicação: 2006 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propilaminas / Transtorno do Deficit de Atenção com Hiperatividade / Inibidores da Captação Adrenérgica Tipo de estudo: Clinical_trials / Guideline / Systematic_reviews Limite: Adolescent / Female / Humans / Male Idioma: En Revista: J Pediatr Ano de publicação: 2006 Tipo de documento: Article