Genome sequence diversity and clues to the evolution of variola (smallpox) virus.
Science
; 313(5788): 807-12, 2006 Aug 11.
Article
em En
| MEDLINE
| ID: mdl-16873609
ABSTRACT
Comparative genomics of 45 epidemiologically varied variola virus isolates from the past 30 years of the smallpox era indicate low sequence diversity, suggesting that there is probably little difference in the isolates' functional gene content. Phylogenetic clustering inferred three clades coincident with their geographical origin and case-fatality rate; the latter implicated putative proteins that mediate viral virulence differences. Analysis of the viral linear DNA genome suggests that its evolution involved direct descent and DNA end-region recombination events. Knowing the sequences will help understand the viral proteome and improve diagnostic test precision, therapeutics, and systems for their assessment.
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Coleções:
01-internacional
Contexto em Saúde:
4_TD
Base de dados:
MEDLINE
Assunto principal:
Vírus da Varíola
/
Variação Genética
/
Varíola
/
DNA Viral
/
Genoma Viral
/
Evolução Molecular
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2006
Tipo de documento:
Article