Your browser doesn't support javascript.
loading
Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists.
Blanc-Delmas, Elodie; Lebegue, Nicolas; Wallez, Valérie; Leclerc, Véronique; Yous, Saïd; Carato, Pascal; Farce, Amaury; Bennejean, Caroline; Renard, Pierre; Caignard, Daniel-Henri; Audinot-Bouchez, Valérie; Chomarat, Pascale; Boutin, Jean; Hennuyer, Nathalie; Louche, Katie; Carmona, Maria Carmen; Staels, Bart; Pénicaud, Luc; Casteilla, Louis; Lonchampt, Michel; Dacquet, Catherine; Chavatte, Philippe; Berthelot, Pascal; Lesieur, Daniel.
Afiliação
  • Blanc-Delmas E; Laboratoire de Chimie Thérapeutique EA1043, Faculté des Sciences Pharmaceutiques et Biologiques de Lille, 3 rue du Professeur Laguesse, B.P. 83 59006 LILLE Cedex, France.
Bioorg Med Chem ; 14(22): 7377-91, 2006 Nov 15.
Article em En | MEDLINE | ID: mdl-16887353
A series of 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles has been synthesized and tested for PPARgamma agonist activity. SAR were developed and revealed that 6-acyl-2(3H)-benzothiazolone derivatives with 1,3-dicarbonyl group were the most potent. IP administration of compound 22 exhibited comparable levels of glucose and triglyceride correction to PO administration of rosiglitazone in the ob/ob mouse studies.
Assuntos
Buscar no Google
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Azo / PPAR gama / Compostos Heterocíclicos Limite: Animals / Female / Humans / Male Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2006 Tipo de documento: Article
Buscar no Google
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Azo / PPAR gama / Compostos Heterocíclicos Limite: Animals / Female / Humans / Male Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2006 Tipo de documento: Article