Synthesis of poly d(G-C) oligonucleotides.
Nucleosides Nucleotides Nucleic Acids
; 25(7): 705-17, 2006.
Article
em En
| MEDLINE
| ID: mdl-16898410
ABSTRACT
Model sequences for evaluation of the GC dimer sequence repetition on synthesis success were prepared and analyzed by HPLC. Contiguous d(G-C) or d(C-G) sequences have a deleterious effect on DNA oligonucleotide synthesis. The critical number seems to be about 6 GCs in a row. If the GCs are separated by other nucleotides, the effect is not as severe.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Polidesoxirribonucleotídeos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Nucleosides Nucleotides Nucleic Acids
Ano de publicação:
2006
Tipo de documento:
Article