Substance P modulates single-channel properties of neuronal nicotinic acetylcholine receptors.
Neuron
; 4(3): 393-403, 1990 Mar.
Article
em En
| MEDLINE
| ID: mdl-1690566
ABSTRACT
Substance P (SP) is present in avian sympathetic ganglia and accelerates the decay rate of acetylcholine (ACh)-evoked macroscopic currents in sympathetic neurons. We demonstrate here that SP modulates ACh-elicited single channels in a manner consistent with an enhancement of ACh receptor (AChR) desensitization. Furthermore, since AChR channel function was monitored in cell-attached patches with SP applied to the extra-patch membrane, the peptide must act via a second messenger mechanism. SP specifically decreases the net ACh-activated single-channel current across the patch membrane by decreasing both channel opening frequency and mean open time kinetics. These experiments demonstrate that a peptide can modulate neuronal AChR function by a second messenger mechanism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Substância P
/
Receptores Nicotínicos
/
Gânglios Simpáticos
/
Canais Iônicos
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Neuron
Ano de publicação:
1990
Tipo de documento:
Article