Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments.
Dev Neurosci
; 28(4-5): 396-409, 2006.
Article
em En
| MEDLINE
| ID: mdl-16943663
ABSTRACT
The immature brain may be particularly vulnerable to injury during critical periods of development. To address the biologic basis for this vulnerability, mice were subjected to traumatic brain injury at postnatal day 21, a time point that approximates that of the toddler-aged child. After motor and cognitive testing at either 2 weeks (juveniles) or 3 months (adults) after injury, animals were euthanized and the brains prepared for quantitative histologic assessment. Brain-injured mice exhibited hyperactivity and age-dependent anxiolysis. Cortical lesion volume and subcortical neuronal loss were greater in brain-injured adults than in juveniles. Importantly, cognitive decline was delayed in onset and coincided with loss of neurons in the hippocampus. Our findings demonstrate that trauma to the developing brain results in a prolonged period of pathogenesis in both cortical and subcortical structures. Behavioral changes are a likely consequence of regional-specific neuronal degeneration.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
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7_ODS3_muertes_prevenibles_nacidos_ninos
Base de dados:
MEDLINE
Assunto principal:
Agitação Psicomotora
/
Encéfalo
/
Lesões Encefálicas
/
Deficiências do Desenvolvimento
/
Transtornos Cognitivos
/
Degeneração Neural
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
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Humans
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Infant
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Male
Idioma:
En
Revista:
Dev Neurosci
Ano de publicação:
2006
Tipo de documento:
Article