Cyclic changes in the vaginal epithelium of normal rhesus macaques.
J Endocrinol
; 190(3): 829-35, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-17003283
ABSTRACT
Studies in nonhuman primates indicate that changes in the thickness and integrity of the vaginal epithelium affect the transmission rates of HIV-1, but few studies have examined the normal variations that may occur in the vagina of normal macaques as a result of aging or changes in the menstrual cycle. This study was conducted to determine if differences occur in the thickness of the vaginal mucosa with age or menses. Vaginal mucosal thickness was compared in 46 rhesus macaques grouped as juvenile (1-3 years old), mature cycling (3-21 years old), and geriatric (> 21 years old). Epithelia of mature cycling macaques were also compared at different stages of the menstrual cycle. Older females (> 21 years) had the thinnest and least keratinized epithelium of all groups, followed by the youngest females (< 3 years). The vaginal epithelium was also thinner in cycling macaques during menses compared to the follicular stage. In addition, young, geriatric, or cycling macaques during menses had minimal keratinization. We hypothesize that normal physiologic changes in the vaginal epithelium of women occur with age and menses, which may affect a woman's susceptibility to HIV-1 transmission and other sexually transmitted diseases. Also, age and menstrual cycle should be considered when designing vaginal transmission experiments in rhesus macaques.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vagina
/
Envelhecimento
/
Epitélio
/
Macaca mulatta
/
Ciclo Menstrual
Limite:
Animals
Idioma:
En
Revista:
J Endocrinol
Ano de publicação:
2006
Tipo de documento:
Article