Protein modification in aging: an update.
Exp Gerontol
; 41(9): 807-12, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-17008045
ABSTRACT
Post-translational modifications of proteins are an important biologic tool for the production of various protein species from a single gene, which may vary in conformation, function, biologic half-life and complex formation with other proteins. The present minireview summarizes a few selected research observations important for the role of post-translational modifications in biologic aging and age-related diseases, including farnesylation, methylglyoxal-derivatization, transglutaminase pathways and the formation of 3-nitrotyrosine and 2-oxo-histidine in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Processamento de Proteína Pós-Traducional
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Exp Gerontol
Ano de publicação:
2006
Tipo de documento:
Article