Hepatitis C virus RNA-dependent RNA polymerase: study on the inhibition mechanism by pyrogallol derivatives.
Biochemistry (Mosc)
; 71(9): 1021-6, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-17009957
ABSTRACT
Pyrogallol reversibly and noncompetitively inhibits the activity of the hepatitis C RNA-dependent RNA polymerase. Based on molecular modeling of the inhibitor binding in the active site of the enzyme, the inhibition was suggested to be realized via chelation of two magnesium cations involved in the catalysis at the stage of the phosphoryl residue transfer. The proposed model allowed us to purposefully synthesize new derivatives with higher inhibitory capacity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirogalol
/
RNA Polimerase Dependente de RNA
/
Hepacivirus
Idioma:
En
Revista:
Biochemistry (Mosc)
Ano de publicação:
2006
Tipo de documento:
Article