Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 16(24): 6226-30, 2006 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-17010607
ABSTRACT
A series of xanthine mimetics containing 5,5 and 5,6 heterocycle fused imidazoles were synthesized as dipeptidyl peptidase IV inhibitors. Compound 7 is potent (h-DPPIV K(i)=2nM) and exhibits excellent selectivity and no species specificity against rat and human enzymes. The X-ray structure confirms that the binding mode of 7 to rat DPPIV is similar to the parent xanthines.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Xantinas
/
Inibidores da Dipeptidil Peptidase IV
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2006
Tipo de documento:
Article