Tandem riboswitch architectures exhibit complex gene control functions.
Science
; 314(5797): 300-4, 2006 Oct 13.
Article
em En
| MEDLINE
| ID: mdl-17038623
ABSTRACT
Riboswitches are structured RNAs typically located in the 5' untranslated regions of bacterial mRNAs that bind metabolites and control gene expression. Most riboswitches sense one metabolite and function as simple genetic switches. However, we found that the 5' region of the Bacillus clausii metE messenger RNA includes two riboswitches that respond to S-adenosylmethionine and coenzyme B12. This tandem arrangement yields a composite gene control system that functions as a two-input Boolean NOR logic gate. These findings and the discovery of additional tandem riboswitch architectures reveal how simple RNA elements can be assembled to make sophisticated genetic decisions without involving protein factors.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
S-Adenosilmetionina
/
Bacillus
/
Regulação Bacteriana da Expressão Gênica
/
Cobamidas
/
Regiões 5' não Traduzidas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Science
Ano de publicação:
2006
Tipo de documento:
Article