Surveillance program for early detection of hepatocellular carcinoma in Japan: results of specialized department of liver disease.
J Clin Gastroenterol
; 40(10): 942-8, 2006.
Article
em En
| MEDLINE
| ID: mdl-17063116
ABSTRACT
OBJECTIVE:
Surveillance of cirrhotic patients enables early detection of hepatocellular carcinoma (HCC) and possibly prolongs survival. The aim of this study was to explore whether early-stage HCC can be detected earlier at a specialized department of liver disease than in other institutions.METHODS:
The study subjects were 574 patients with HCC. Patients were subdivided into 3 groups according to the manner of HCC detection group A, HCC was detected in 91 patients during periodic examination at Kurume University School of Medicine; group B, HCC was detected in 301 patients during periodic examination at other institutions; group C, HCC was detected incidentally or because of symptoms in 182 patients.RESULTS:
The HCC detected in group A was significantly of smaller size (20.4 mm) compared with groups B (27.1 mm, P<0.0001) and C (57.8 mm, P<0.0001). The frequency of receiving treatment (surgery or local ablation therapy) was significantly higher in group A (73%) than in groups B (52%, P=0.002) and C (26%, P<0.0001). The 5-year survival rates were 52% for group A, 40% for group B, and 23% for group C, respectively. The survival of group A was significantly better than that of groups B (P=0.0157) and C (P<0.0001).CONCLUSIONS:
Surveillance for HCC at specialized Department of Liver Disease can detect early-stage HCC, resulting in a higher chance of receiving promising treatment.
Buscar no Google
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Vigilância da População
/
Carcinoma Hepatocelular
/
Departamentos Hospitalares
/
Neoplasias Hepáticas
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Clin Gastroenterol
Ano de publicação:
2006
Tipo de documento:
Article