Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG.
Bioorg Med Chem Lett
; 17(3): 814-8, 2007 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-17107791
ABSTRACT
Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists with greater selectivity over hERG were identified. SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Bifenilo
/
Receptores de Somatostatina
/
Bloqueadores dos Canais de Potássio
/
Canais de Potássio Éter-A-Go-Go
/
Naftalenos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2007
Tipo de documento:
Article