[Clinical effect of shenbing mistura combined with glucocorticoid on recurrent nephrotic syndrome in children and levels of interleukin-6 and tumor necrosis factor-alpha in blood and urine].
Zhongguo Zhong Xi Yi Jie He Za Zhi
; 26(10): 892-5, 2006 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-17121039
ABSTRACT
OBJECTIVE:
To study the effect of Shenbing Mistura (SM) combined with glucocorticoid on recurrent nephrotic syndrome (RNS) in children and levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in blood and urine.METHODS:
The treatment group was treated with SM plus glucocorticoid, the control group with glucocorticoid alone, and a healthy control group was adopted, 30 cases in each group. The clinical effect and recurrence rate were observed, and levels of IL-6 and TNF-alpha in blood and urine were determined before treatment and at the 4th, 8th, 12th week after treatment.RESULTS:
Significant difference of IL-6 and TNF-alpha levels in blood and urine was found in either the pre- and post- treatment auto-control of both the treatment group and control group, or in the inter-group comparison of them (P < 0.01); clinical effect also showed remarkable difference between the two groups (P < 0.01). Furthermore, the recurrence rate of the treatment group was lower than that of the control group showed by a 18-month follow-up (P < 0.01).CONCLUSION:
SM combined with glucocorticoid could significantly reduce the recurrence rate and elevate the clinical effect in children with RNS, it could also lower the levels of IL-6 and TNF-alpha in patients' blood and urine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prednisona
/
Medicamentos de Ervas Chinesas
/
Interleucina-6
/
Fator de Necrose Tumoral alfa
/
Fitoterapia
/
Síndrome Nefrótica
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhongguo Zhong Xi Yi Jie He Za Zhi
Ano de publicação:
2006
Tipo de documento:
Article