[Intratympanic treatment in Meniere's disease: the effect of gentamicin and dexamethasone on vertigo control and hearing]. / Meniere hastalginda intratimpanik tedavi: Gentamisin ve deksametazonun vertigo kontrolü ve isitme üzerine etkisi.
Kulak Burun Bogaz Ihtis Derg
; 16(5): 193-9, 2006.
Article
em Tr
| MEDLINE
| ID: mdl-17124437
ABSTRACT
OBJECTIVES:
We investigated the effect of intratympanic gentamicin and dexamethasone treatments on the control of vertigo and hearing loss in patients with Meniere's disease. PATIENTS ANDMETHODS:
Forty-five patients with a diagnosis of Meniere's disease according to the 1995 criteria of American Academy of Otorhinolaryngology Head and Neck Surgery were assigned to receive intratympanic gentamicin (40 mg/ml, 0.7 ml; n=24; 11 males, 13 females; mean age 46 years) or dexamethasone (4 mg/ml, 0.7 ml; n=21; 8 males, 13 females; mean age 50.4 years). The results were evaluated with respect to changes in vertigo and hearing symptoms.RESULTS:
In the gentamicin group, vertigo symptoms were controlled in 22 patients (92%), deterioration in hearing was seen in only two patients (8%). In the dexamethasone group, nine patients had complete follow-up. Of these, vertigo control was achieved in six patients (67%), none had worsened hearing, and one patient (5%) had improved hearing. When improvement in hearing was defined as at least a 5 dB change, then five patients (24%) benefited from treatment.CONCLUSION:
Intratympanic treatment modalities in Meniere's disease are easy to perform, cheap, and effective. They are expected to have a more extensive use with higher success rates in the future.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membrana Timpânica
/
Dexametasona
/
Gentamicinas
/
Doença de Meniere
/
Anti-Inflamatórios
/
Antibacterianos
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Tr
Revista:
Kulak Burun Bogaz Ihtis Derg
Ano de publicação:
2006
Tipo de documento:
Article