[Study of mutation and single nucleotide polymorphism of PDGFRbeta and SHIP gene in acute myeloid leukemia].
Zhonghua Xue Ye Xue Za Zhi
; 27(6): 383-5, 2006 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-17147227
ABSTRACT
OBJECTIVE:
To investigate the significance of mutation and single nucleotide polymorphism (SNP) of class III receptor tyrosine kinases such as PDGFRbeta and SHIP in acute myeloid leukemia (AML) patients.METHODS:
Screening of the mutation and SNP of PDGFRbeta and SHIP by genomic PCR, RT-PCR, directly sequencing and Mass-ARRAY system was carried out in 273 AML patients.RESULTS:
The mutations of PDGFRbeta R685C and SHIP Q1153L were detected for the first time in AML patients. The positivity ratio was 0.73% and 0.36% respectively.CONCLUSION:
The mutations of PDGFRbeta R685C and SHIP Q1153L may contribute to leukemogenesis of AML.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Receptor beta de Fator de Crescimento Derivado de Plaquetas
/
Fosfatos de Inositol
Limite:
Humans
Idioma:
Zh
Revista:
Zhonghua Xue Ye Xue Za Zhi
Ano de publicação:
2006
Tipo de documento:
Article