Changes in plasma metabolites and muscle glycogen are correlated to bovine spongiform encephalopathy in infected dairy cattle.
Res Vet Sci
; 83(1): 40-6, 2007 Aug.
Article
em En
| MEDLINE
| ID: mdl-17197001
ABSTRACT
During the clinical phase of bovine spongiform encephalopathy (BSE), a significant decrease was observed in the ratio of muscle glycogen to plasma L-lactic acid concentrations in BSE infected field case and experimentally infected dairy cattle compared with healthy control cattle (P<0.001), this being due to changes in the concentration of both metabolites in the BSE infected cattle compared with the control group. Furthermore, the concentration of plasma alanine was significantly increased (P<0.05) in the infected animals. No significant difference was detected between these two groups in the ratio of hepatic glycogen to plasma lactate. We infer that BSE infected cattle exhibit signs of altered energy metabolism and when applied in conjunction with changes in other metabolite biomarkers these changes may be useful for discriminating BSE infected cattle from healthy cattle or those suffering with other disorders or diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalopatia Espongiforme Bovina
/
Músculo Esquelético
/
Glicogênio
Limite:
Animals
Idioma:
En
Revista:
Res Vet Sci
Ano de publicação:
2007
Tipo de documento:
Article