Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution.

Haak, Robert M; Tarabiono, Chiara; Janssen, Dick B; Minnaard, Adriaan J; de Vries, Johannes G; Feringa, Ben L

Haak, Robert M; Tarabiono, Chiara; Janssen, Dick B; Minnaard, Adriaan J; de Vries, Johannes G; Feringa, Ben L.

Afiliação

Haak RM; Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.

Org Biomol Chem ; 5(2): 318-23, 2007 Jan 21.

Article em En | MEDLINE | ID: mdl-17205176

ABSTRACT

ABSTRACT

3-Alkenyl and heteroaryl chloroalcohols have been obtained in excellent enantiomeric excess (>99%) by enzymatic kinetic resolution using the haloalcohol dehalogenase HheC. Yields were close to the theoretical maximum for all substrates employed. Furthermore, the applicability of this methodology on multigram scale has been established.

Assuntos

Álcoois/química; Cloro/química; Catálise; Cromatografia em Camada Fina; Hidrolases/química; Hidrólise; Cinética; Modelos Químicos; Conformação Molecular; Estrutura Molecular; Estereoisomerismo; Temperatura

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cloro / Álcoois Idioma: En Revista: Org Biomol Chem Ano de publicação: 2007 Tipo de documento: Article

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