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Mendelian analysis of a metastasis-prone substrain of BALB/c nude mice using a subcutaneously inoculated human tumour.
Schou, M; Brünner, N; Spang-Thomsen, M; Rygaard, J.
Afiliação
  • Schou M; Bartholin Instituttet, Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. morten.schou@rh.hosp.dk
APMIS ; 114(12): 899-907, 2006 Dec.
Article em En | MEDLINE | ID: mdl-17207091
Most nude mice do not allow the formation of metastases after heterotransplantation of human malignant tumours. Here we describe a substrain of BALB/c nude mice (BALB/c/AnNCr) that reproducibly allows some human cancers to metastasize. By Mendelian analysis of hybrids between this substrain and C57BL/6J +/+ mice we found that the ability to allow a human tumour (MDA-MB-435 BAG) to express its metastatic phenotype is determined by a recessively inheritable trait in the mouse host. We are presently working to identify the genetics responsible for development of metastases. The study also includes immunohistochemical and electron microscopic analysis of the test tumour, originally assumed to be a human mammary carcinoma, but shown to possess characteristics of a malignant melanoma (1). The ultimate aim of our ongoing study is to establish a substrain of nude mice that will allow metastasis in all recipients.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Modelos Animais de Doenças / Neoplasias Pulmonares / Camundongos Endogâmicos BALB C Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: APMIS Ano de publicação: 2006 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Modelos Animais de Doenças / Neoplasias Pulmonares / Camundongos Endogâmicos BALB C Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: APMIS Ano de publicação: 2006 Tipo de documento: Article