Quantitative interpretation of MALDI-TOF mass spectra of imperfect carbosilane dendrimers.
Anal Chem
; 79(4): 1639-45, 2007 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-17297967
ABSTRACT
A general relationship is derived for the abundance of an imperfect dendrimer with a given number of missing constitutional repeating units in the two outmost layers. The relationship is used in the interpretation of the MALDI TOF mass spectrum of the second-generation carbosilane dendrimer prepared by the iterative divergent method. The model quantitatively describes the spectrum of the dendrimer and correctly predicts the MALDI TOF mass spectrum of its first-generation precursor. Thus, the use of well-resolved MALDI TOF mass spectra for assessing the purity of low-generation dendrimers with uniform end groups is substantiated for carbosilane dendrimers and to lesser extent for dendrimers in general.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Silanos
/
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
/
Dendrímeros
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
Anal Chem
Ano de publicação:
2007
Tipo de documento:
Article