Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: a combined medicinal chemistry, NMR and computational chemistry approach.
Bioorg Med Chem
; 15(7): 2690-700, 2007 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-17306550
ABSTRACT
We have previously reported the discovery and initial SAR optimization of the first series of inhibitors of the human papillomavirus type-11 (HPV11) E1-E2 protein-protein interaction. These inhibitors featured an indandione system spiro-fused onto an all syn substituted tetrahydrofuran ring. In this paper, we report new SAR efforts which have led to the identification of the first low nanomolar inhibitor of the HPV11 E1-E2 protein-protein interaction. In addition, we report a combined NMR and computational chemistry approach which allowed the successful determination of the absolute stereochemistry of the active species originating from the initial racemic lead.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Proteínas Virais
/
Proteínas de Ligação a DNA
/
Papillomavirus Humano 11
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Ano de publicação:
2007
Tipo de documento:
Article