Non-effect of p22-phox -930A/G polymorphism on end-organ damage in Brazilian hypertensive patients.
J Hum Hypertens
; 21(6): 504-6, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17314996
ABSTRACT
The p22-phox subunit is an essential component of NAD(P)H oxidase enzymatic complex, which is considered the major source of oxidative stress products in the cardiovascular system. The -930G allele of p22-phox has been associated with higher promoter activity, increased NAD(P)H oxidase-mediated oxidative stress and hypertension. We recently reported that left ventricular hypertrophy is accompanied by increased myocardial p22-phox expression in aortic-banded rats, suggesting that this protein might be involved in hypertensive cardiac hypertrophy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
NADPH Oxidases
/
Hipertensão
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J Hum Hypertens
Ano de publicação:
2007
Tipo de documento:
Article