Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083.
J Antibiot (Tokyo)
; 59(12): 785-90, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17323645
ABSTRACT
A new NADH-fumarate reductase inhibitor, verticipyrone, was isolated from the cultured broth of a fungus, Verticillium sp. FKI-1083. The structure was established as (E)-2-methoxy-3,5-dimethyl-6-(3-methyl-2-undecenyl)-4H-pyran-4-one. Verticipyrone exhibited an IC50 value of 0.88 nM against NADH-fumarate reductase of Ascaris suum. Verticipyrone inhibited both Ascaris and bovine heart complex I, and its synthetic analogue, 8,9-dihydro-8-hydroxyverticipyrone, showed good selectivity against Ascaris complex I.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pironas
/
Verticillium
/
Oxirredutases atuantes sobre Doadores de Grupo CH-CH
/
Alcenos
/
Inibidores Enzimáticos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
2006
Tipo de documento:
Article