Paracetamol inhibits nitric oxide synthesis in murine spinal cord slices.
Eur J Pharmacol
; 562(1-2): 68-71, 2007 May 07.
Article
em En
| MEDLINE
| ID: mdl-17331495
ABSTRACT
Paracetamol is an effective analgesic but its mechanism of action is unclear. We investigated the effect of paracetamol and the analgesic adjuvant caffeine on the activity of NO synthase in mouse spinal cord and cerebellar slices in vitro, by measuring the conversion of [(3)H]arginine to [(3)H]citrulline. Paracetamol (100 microM) had no effect on NO synthase activity in cerebellum, but in the spinal cord both paracetamol (100 microM) and caffeine (30 microM) attenuated glutamate (5 mM)-induced [(3)H]citrulline production and in combination they abolished it. In conclusion paracetamol inhibits spinal cord NO synthesis and this may be related to its analgesic effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Acetaminofen
/
Óxido Nítrico
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2007
Tipo de documento:
Article