Serum cystatin C as a better marker of vancomycin clearance than serum creatinine in elderly patients.
Clin Biochem
; 40(7): 485-90, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17336280
ABSTRACT
OBJECTIVES:
The purpose of this study is to assess the usefulness of the concentration of cystatin C (Cys-C) in serum for predicting the clearance of vancomycin (CLvcm) compared with the serum concentration of creatinine (SCr) in the elderly.METHODS:
Thirty-nine serum samples were obtained from 24 elderly patients (65 years and older). Creatinine clearance (CLcr) and the glomerular filtration rate calculated from the concentration of Cys-C (GFRcys-c) were estimated using Cockcroft & Gault's formula and Larsson's formula, respectively.RESULTS:
The correlation constant for CLvcm and the reciprocal of Cys-C (p=0.883) was significantly higher than that for CLvcm and the reciprocal of SCr (p=0.575, p<0.005). GFRcys-c was strongly correlated with CLvcm (p=0.883) and the constant was significantly higher than that for the correlation between CLvcm and CLcr (p=0.684, p<0.05). These results suggest that the serum concentration of Cys-C is a more reliable marker for predicting CLvcm than is SCr in elderly patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vancomicina
/
Biomarcadores
/
Cistatinas
/
Creatinina
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Biochem
Ano de publicação:
2007
Tipo de documento:
Article