The first asymmetric total syntheses and determination of absolute configurations of xestodecalactones B and C.
J Org Chem
; 72(7): 2694-7, 2007 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-17346089
ABSTRACT
The first efficient asymmetric total syntheses of xestodecalactones B and C have been accomplished in 10 steps with an overall yield of 22 and 20.2%, respectively. The key steps involve the utility of Evans oxazolidinone-mediated syn-aldol condensations to establish the C-9 configuration and the macrolide ring formation by intramolecular acylation. The absolute configurations of xestodecalactones B and C have been determined via these syntheses.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lactonas
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2007
Tipo de documento:
Article