Functional outcome in bipolar disorder: the role of clinical and cognitive factors.
Bipolar Disord
; 9(1-2): 103-13, 2007.
Article
em En
| MEDLINE
| ID: mdl-17391354
ABSTRACT
INTRODUCTION:
Few studies have examined the clinical, neuropsychological and pharmacological factors involved in the functional outcome of bipolar disorder despite the gap between clinical and functional recovery.METHODS:
A sample of 77 euthymic bipolar patients were included in the study. Using an a priori definition of low versus good functional outcome, based on the psychosocial items of the Global Assessment of Functioning (GAF, DSM-IV), and taking also into account their occupational adaptation, the patients were divided into two groups good or low occupational functioning. Patients with high (n = 46) and low (n = 31) functioning were compared on several clinical, neuropsychological and pharmacological variables and the two patient groups were contrasted with healthy controls (n = 35) on cognitive performance.RESULTS:
High- and low-functioning groups did not differ with respect to clinical variables. However, bipolar patients in general showed poorer cognitive performance than healthy controls. This was most evident in low-functioning patients and in particular on verbal memory and executive function measures.CONCLUSIONS:
Low-functioning patients were cognitively more impaired than highly functioning patients on verbal recall and executive functions. The variable that best predicted psychosocial functioning in bipolar patients was verbal memory.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ajustamento Social
/
Antipsicóticos
/
Transtorno Bipolar
/
Transtornos Cognitivos
/
Emprego
/
Antidepressivos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Bipolar Disord
Ano de publicação:
2007
Tipo de documento:
Article