Prophylactic intravesical instillation of epinephrine prevents cyclophosphamide-induced hemorrhagic cystitis in rats.
Exp Biol Med (Maywood)
; 232(4): 565-70, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17392493
ABSTRACT
The objective of this study is to investigate the potential protective effects of intravesical instillation of epinephrine in cyclophosphamide-induced hemorrhagic cystitis. In an earlier study, we have shown that epinephrine promotes hemostasis on established hemorrhagic cystitis induced by cyclophosphamide. Female Sprague-Dawley rats were divided into seven groups as follows group 1 positive control (150 mg/kg, cyclophosphamide, i.p.), group 2 negative control (10 microg/ml, epinephrine, intravesical), co-administration of cyclophosphamide (150 mg/kg, i.p.), group 3 saline (intravesical), groups 4-6 epinephrine (2.5, 5, and 10 mu g/ml, intravesical), and group 7 mesna (50 mg/kg, i.p.). Rats were sacrificed on 3 consecutive days and the urinary bladders were removed, weighed, and evaluated. The vesical vascular permeability was determined by wet bladder weight and Evan's blue dye absorbance. After 24 hours of cyclophosphamide administration, severe hemorrhagic cystitis was induced with marked edema, hemorrhage, and inflammation. In the epinephrine-treated groups, symptoms of hemorrhagic cystitis (such as edema, inflammation, and hemorrhage) were reduced significantly. Intravesical instillation of epinephrine prevents edema, hemorrhage, and inflammation in rats with cyclophosphamide-induced hemorrhagic cystitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasoconstritores
/
Epinefrina
/
Antineoplásicos Alquilantes
/
Ciclofosfamida
/
Cistite
/
Hemorragia
Limite:
Animals
Idioma:
En
Revista:
Exp Biol Med (Maywood)
Ano de publicação:
2007
Tipo de documento:
Article