Regulation of the NADPH oxidase activity and anti-microbial function of neutrophils by arachidonic acid.
Arch Immunol Ther Exp (Warsz)
; 55(2): 99-110, 2007.
Article
em En
| MEDLINE
| ID: mdl-17417690
ABSTRACT
Arachidonic acid (AA), a second-messenger molecule released from membrane phospholipids by phospholipase A(2) in activated cells, is a stimulator of neutrophil responses, including the oxygen-dependent respiratory burst. The polyunsaturated fatty acid is also the precursor of biologically active eicosanoids. There are several mechanisms by which AA stimulates the respiratory burst. These include the direct binding of AA to S100 proteins which regulate the assembly of the NADPH oxidase as well as the activation of key signaling molecules which control the respiratory burst. Arachidonic acid also stimulates it own release from membrane phospholipids and this contributes to optimal respiratory burst activity. Thus, increased levels of AA at sites of inflammation will influence the magnitude and course of the inflammatory response, not only by directly affecting the function of infiltrating neutrophils and other leukocytes, but also through its metabolites generated by lipoxygenases and cyclooxygenases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação Enzimológica da Expressão Gênica
/
Ácido Araquidônico
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NADPH Oxidases
/
Neutrófilos
Limite:
Humans
Idioma:
En
Revista:
Arch Immunol Ther Exp (Warsz)
Ano de publicação:
2007
Tipo de documento:
Article