Application of the intramolecular Yamamoto vinylogous aldol reaction to the synthesis of macrolides.
Org Lett
; 9(11): 2103-6, 2007 May 24.
Article
em En
| MEDLINE
| ID: mdl-17455940
ABSTRACT
An intramolecular version of the Yamamoto vinylogous aldol reaction, a method that employs the bulky Lewis acid ATPH to control the site of aldolization, is described. This macrocyclization process is effective for the construction of 10-, 12-, and 14-membered macrolides. The yields are high (70-90%), and the reaction can proceed with excellent remote stereocontrol (dr > or = 201) with chiral substrates.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Macrolídeos
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2007
Tipo de documento:
Article