Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.
Int J Oncol
; 30(6): 1529-37, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17487375
Honokiol (HNK), a naturally occurring biphenyl, possesses potent antineoplastic and antiangiogenic properties. We investigated the in vitro and in vivo activity of HNK against breast cancer. HNK exhibited potent anti-proliferative activity against breast cancer cell lines and enhanced the activity of other drugs used for the treatment of breast cancer. In vivo, HNK was highly effective against breast cancer in nude mice. We identified two different effects of HNK on breast cancer cells: cell cycle inhibition, observed at lower doses of HNK, and induction of apoptosis, observed at higher doses of the compound. Our data suggest that HNK is a systemically available, non-toxic inhibitor of breast cancer growth and should be examined for clinical applications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Bifenilo
/
Neoplasias da Mama
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Apoptose
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Lignanas
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Antineoplásicos Fitogênicos
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Int J Oncol
Ano de publicação:
2007
Tipo de documento:
Article