Matrices and scaffolds for drug delivery in dental, oral and craniofacial tissue engineering.
Adv Drug Deliv Rev
; 59(4-5): 308-24, 2007 May 30.
Article
em En
| MEDLINE
| ID: mdl-17499385
ABSTRACT
Current treatments for diseases and trauma of dental, oral and craniofacial (DOC) structures rely on durable materials such as amalgam and synthetic materials, or autologous tissue grafts. A paradigm shift has taken place to utilize tissue engineering and drug delivery approaches towards the regeneration of these structures. Several prototypes of DOC structures have been regenerated such as temporomandibular joint (TMJ) condyle, cranial sutures, tooth structures and periodontium components. However, many challenges remain when taking in consideration the high demand for esthetics of DOC structures, the complex environment and yet minimal scar formation in the oral cavity, and the need for accommodating multiple tissue phenotypes. This review highlights recent advances in the regeneration of DOC structures, including the tooth, periodontium, TMJ, cranial sutures and implant dentistry, with specific emphasis on controlled release of signaling cues for stem cells, biomaterial matrices and scaffolds, and integrated tissue engineering approaches.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Periodontais
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Regeneração
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Articulação Temporomandibular
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Doenças Dentárias
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Materiais Biocompatíveis
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Sistemas de Liberação de Medicamentos
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Anormalidades Craniofaciais
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Engenharia Tecidual
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Peptídeos e Proteínas de Sinalização Intercelular
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Implantação Dentária
Limite:
Humans
Idioma:
En
Revista:
Adv Drug Deliv Rev
Ano de publicação:
2007
Tipo de documento:
Article