Gata1 regulates dendritic-cell development and survival.
Blood
; 110(6): 1933-41, 2007 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-17505015
ABSTRACT
Dendritic cells are key initiators and regulators of the immune response. Dendritic cell commitment and function require orchestrated regulation of transcription. Gata1 is a transcription factor expressed in several hematopoietic lineages. However, Gata1 function has not been explored in the monocytic or dendritic cell compartment. Here, we show that Gata1 is expressed in myeloid and plasmacytoid dendritic cells and that Gata1 ablation affects the survival of dendritic cells. Furthermore, lipopolysaccharide (LPS) stimulation of dendritic cells prompts Gata1 up-regulation, which is accompanied by increased levels of BclX and Ifng. Our findings show that Gata1 is a transcriptional regulator of dendritic cell differentiation and suggest that Gata1 is involved in the dendritic cell and macrophage lineage separation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Diferenciação Celular
/
Sobrevivência Celular
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Linhagem da Célula
/
Fator de Transcrição GATA1
Limite:
Animals
Idioma:
En
Revista:
Blood
Ano de publicação:
2007
Tipo de documento:
Article