Novel potential drug against T. cruzi and its interaction with surfactant micelles.
Pharm Dev Technol
; 12(2): 183-92, 2007.
Article
em En
| MEDLINE
| ID: mdl-17510890
ABSTRACT
The interaction of 5-nitro-2-furfurilylidene benzhydrazide (5NFB), potential anti-trypanosomal compound, with micellar solutions was studied. The results indicated that 50 mug of 5NFB completely kills 20 million T. cruzi epimastigote cells within 3 days, whereas the same amount of benznidazole kills 30% of the cells after 4 days. 5NFB solubility in surfactants solutions (SDS, DTAB, C12EO8) increased linearly with surfactant concentration. According to small angle X-ray scattering (SAXS), 5NFB does not affect micellar structural features. A comparison between C12EO8 effects on T. cruzi epimastigote cells and on erythrocytes showed that surfactant lytic effect is stronger in parasite cells, enlightening the potential of 5NFB micellar formulations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tensoativos
/
Tripanossomicidas
/
Trypanosoma cruzi
/
Hidrazonas
/
Micelas
/
Nitrofuranos
Limite:
Animals
Idioma:
En
Revista:
Pharm Dev Technol
Ano de publicação:
2007
Tipo de documento:
Article