Development of an instrument for measurement of light scattering at the corneal epithelial basement membrane in diabetic patients.
Jpn J Ophthalmol
; 51(3): 185-90, 2007.
Article
em En
| MEDLINE
| ID: mdl-17554480
ABSTRACT
PURPOSE:
Diabetic complications are associated with abnormality of the basement membranes. We have developed a light-scattering detection system (LSDS) specifically for measurement of light scattering at the corneal epithelial basement membrane, and have determined the reproducibility and clinical significance of the results obtained by the LSDS in diabetic patients.METHODS:
Thirty nondiabetic controls and 40 diabetic subjects participated in the study. Light scattering at the corneal epithelial basement membrane was measured with the LSDS.RESULTS:
The measurement of light scattering at the corneal basement membrane was found to be reproducible. The LSDS index (mean +/- SD) was 28.1 +/- 4.8 in controls, 35.7 +/- 6.3 in mild diabetic retinopathy subjects, and 42.7 +/- 8.6 in severe diabetic retinopathy subjects. This demonstrated that the LSDS index at the corneal basement membrane is proportional to the extent of diabetic retinopathy.CONCLUSIONS:
Measurement of light scattering at the corneal epithelial basement membrane is possible with the LSDS, is relatively easy to perform, and is reproducible. The LSDS may prove suitable for the early detection of diabetic ocular complications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membrana Basal
/
Epitélio Corneano
/
Doenças da Córnea
/
Complicações do Diabetes
/
Técnicas de Diagnóstico Oftalmológico
Tipo de estudo:
Etiology_studies
/
Evaluation_studies
/
Screening_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Jpn J Ophthalmol
Ano de publicação:
2007
Tipo de documento:
Article