A combination of lidocaine (lignocaine) and remifentanil reduces pain during propofol injection.
Clin Drug Investig
; 27(7): 493-7, 2007.
Article
em En
| MEDLINE
| ID: mdl-17563129
ABSTRACT
OBJECTIVE:
Pain on injection is a well known adverse effect of propofol. The purpose of this study was to compare the analgesic effect of a lidocaine (lignocaine)/remifentanil combination compared with either lidocaine alone or remifentanil alone during propofol injection for induction of anaesthesia.METHODS:
In a randomised, double-blind, prospective trial, 129 patients were allocated to one of three groups (each n = 43) receiving lidocaine 20mg, remifentanil 0.3 microg/kg or lidocaine 20 mg plus remifentanil 0.3 microg/kg as pretreatment, followed by injection of 5 mL of 1% propofol. Pain severity was evaluated on a four-point scale.RESULTS:
Two patients (4.7%) complained of pain in the lidocaine plus remifentanil group compared with 15 (35.7%) in the lidocaine alone group and 18 (42.9%) in the remifentanil alone group (p < 0.001). There was no significant difference in the incidence of injection pain between the lidocaine alone and remifentanil alone groups (p = 0.21).CONCLUSION:
Pretreatment with a combination of lidocaine and remifentanil is more effective than either pretreatment alone in reducing pain on injection of propofol.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Piperidinas
/
Propofol
/
Anestésicos Intravenosos
/
Analgésicos Opioides
/
Anestésicos Locais
/
Lidocaína
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Drug Investig
Ano de publicação:
2007
Tipo de documento:
Article