Differential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progression.
J Mammary Gland Biol Neoplasia
; 12(2-3): 127-33, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17564818
ABSTRACT
The cadherin family of adhesion molecules regulates cell-cell interactions during development and in tissues. The prototypical cadherin, E-cadherin, is responsible for maintaining interactions of epithelial cells and is frequently downregulated during tumor progression. N-cadherin, normally found in fibroblasts and neural cells, can be upregulated during tumor progression and can increase the invasiveness of tumor cells. The proinvasive effects of N-cadherin expression in tumor cells result from two possible mechanisms promotion of tumor cell interactions with the N-cadherin-expressing microenvironment, or enhancement of signaling via the fibroblast growth factor receptor. The downregulation of E-cadherin and the upregulation of N-cadherin in tumors may be a result of an epithelial to mesenchymal transformation (EMT) of tumor cells, which is notoriously difficult to detect in vivo. Double labeling of individual tumors with specific E- and N-cadherin antibodies suggests that EMT can occur heterogeneously and/or transiently within an invasive tumor.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Caderinas
/
Células Epiteliais
/
Mesoderma
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Mammary Gland Biol Neoplasia
Ano de publicação:
2007
Tipo de documento:
Article