Pulmonary Mycobacterium avium complex infection associated with the IVS8-T5 allele of the CFTR gene.
Int J Tuberc Lung Dis
; 11(7): 808-13, 2007 Jul.
Article
em En
| MEDLINE
| ID: mdl-17609059
ABSTRACT
BACKGROUND:
The T5 allele in intron 8 (IVS8) on specific haplotype backgrounds (e.g., long TG repeats) causes abnormal splicing in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and is also known to be associated with chronic airway diseases.OBJECTIVE:
To investigate the role of CFTR variations for susceptibility to pulmonary Mycobacterium avium complex (MAC) infection.PARTICIPANTS:
Three hundred patients with pulmonary MAC infection (72 males, 228 females; mean age at onset 61.6 + or - 12.4 years) took part in this study. Diagnosis of MAC infection was based on American Thoracic Society criteria. Clinical profiles were collected and blood samples were genotyped for TG repeats, poly-T and M470V polymorphisms.RESULTS:
We found significantly higher T5 frequency in MAC patients than in healthy controls from our own study (0.035 and 0.005, respectively, P = 0.023) and other reports. Homozygote for the T5 allele was found in two MAC patients. All T5 alleles were associated with longer TG repeats, the TG12 or TG13 allele. Seventeen of the 21 T5 alleles appeared to be associated with the V470 allele. Other polymorphisms did not show any significant differences in frequency.CONCLUSIONS:
These findings suggest that the IVS8 5T allele might be involved in susceptibility to pulmonary MAC infection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecção por Mycobacterium avium-intracellulare
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Regulador de Condutância Transmembrana em Fibrose Cística
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Predisposição Genética para Doença
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Pneumopatias
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Int J Tuberc Lung Dis
Ano de publicação:
2007
Tipo de documento:
Article