The genetic basis of variation in susceptibility to infection with Histoplasma capsulatum in the mouse.
Genes Immun
; 8(6): 468-74, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17625601
ABSTRACT
The pathogenic fungus Histoplasma capsulatum causes disease ranging from mild to fatal in healthy and immunocompromised humans. Infection rates reach 80% in endemic areas, including the Midwestern United States. We used inbred mice to identify a 300-fold difference in fungal burden. A/J mice showed lower fungal burden and morbidity than C57BL/6J mice, a reversal of the trend observed for many bacterial pathogens. We mapped the differences in fungal burden to discrete locations on chromosomes 1, 6, 15 and 17 with high significance. Substitution of a single resistant chromosome 17 onto the susceptible background was sufficient to lower fungal burden. These loci will allow dissection of the fungal-specific immune program.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Baço
/
Cromossomos de Mamíferos
/
Histoplasma
/
Histoplasmose
/
Pulmão
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Genes Immun
Ano de publicação:
2007
Tipo de documento:
Article