[Immunosorption of individual HIV proteins and virions]. / Immunosorbtsiia individual'nykh bel'kov i virionov VICh.
Vestn Akad Med Nauk SSSR
; (11): 60-3, 1991.
Article
em Ru
| MEDLINE
| ID: mdl-1767581
ABSTRACT
Immunosorbents specifically binding native (gp160, gp120, gp41) and recombinant env proteins and HIV-I virions were synthesized on the basis of Sepharose 4B and Silica with immobilized ligands such as gamma-fraction of rabbit antiserum to HIV-I proteins and purified antibodies to env proteins of HIV-I. The possibility was shown of selective extraction of HIV-I virions and individual HIV proteins both in vitro and in vivo. The titer of virus antigens (in ELISA) after perfusion via an immunosorbent of patterns with a high content of virions and HIV-I proteins was 8 times as low as the starting titer (after perfusion via the control sorbent it was 2-fold decreased). Extracorporeal immunosorption in animals after intravenous injection of recombinant env protein permitted the latter's titer to be 5 times lower. After perfusion via the control sorbent the titer dropped by at least 20% as compared with the starting titer. The possibility of using immunosorption in multimodality therapy of AIDS is under discussion.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
/
Vírion
/
Proteínas Recombinantes
/
Proteínas do Envelope Viral
/
Técnicas de Imunoadsorção
/
HIV-1
Limite:
Animals
Idioma:
Ru
Revista:
Vestn Akad Med Nauk SSSR
Ano de publicação:
1991
Tipo de documento:
Article