Langerhans cell hyperplasia in scabies: a mimic of Langerhans cell histiocytosis.
J Cutan Pathol
; 34(9): 716-20, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17696920
ABSTRACT
AIM:
In the absence of mites, the histologic diagnosis of human scabies can be difficult. Scabies can mimic a variety of inflammatory and lymphoproliferative disorders. It is under-recognized that scabies can also mimic Langerhans cell histiocytosis.METHODS:
Sixteen examples of scabies were reviewed histologically and immunohistochemically (CD1a, CD3, CD20, CD30 and S100).RESULTS:
Immunohistochemical labeling showed florid CD1a and S100 positivity in most cases, indicative of Langerhans cell hyperplasia. Scattered CD30+ lymphocytes were also typically present, within a dense infiltrate, primarily composed of T lymphocytes and eosinophils.CONCLUSION:
Because of the prominent CD1a+/S100+ component, scabies can mimic Langerhans cell histiocytosis. This finding should be considered in conjunction with scattered CD30+ cells and clinical features to avoid misdiagnosis.
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Coleções:
01-internacional
Contexto em Saúde:
4_TD
Base de dados:
MEDLINE
Assunto principal:
Escabiose
/
Células de Langerhans
/
Histiocitose de Células de Langerhans
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Infant
/
Male
/
Middle aged
Idioma:
En
Revista:
J Cutan Pathol
Ano de publicação:
2007
Tipo de documento:
Article